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August 1984

Effect of a Single Brief Seizure on Subsequent Seizure Susceptibility in the Immature Rat

Author Affiliations

From the Newington (Conn) Children's Hospital and University of Connecticut Health Center, Farmington (Dr Holmes) and the Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY (Drs Albala and Moshé).

Arch Neurol. 1984;41(8):853-855. doi:10.1001/archneur.1984.04050190059014

• To determine whether a single seizure permanently affects the brain's susceptibility to further seizures, 27-day-old rats were subjected to a single seizure induced by either an electroshock or the administration of pentylenetetrazol. Three days following the seizure, the rats, along with age- and weight-matched control rats, underwent kindling. The rate of kindling did not differ between the control rats and those rats that had previously experienced a single electroshock or pentylenetetrazol-induced seizure. At the present time, there is no conclusive evidence that a single brief seizure results in permanently increased susceptibility to future convulsions.

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