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September 1984

Plasmapheresis in Neurologic Disease

Author Affiliations

Department of Clinical Neurological Sciences Division of Neurology, Room 70P27 University Hospital PO Box 5339 Postal Station A London, Ontario, Canada N6A 5A5

Arch Neurol. 1984;41(9):915. doi:10.1001/archneur.1984.04050200017004

Letters to the editor should be submitted as an original and two duplicates. They should be typewritten doublespaced on plain bond paper; they will be subject to editing. If they are prepared on a word processor, do not justify the right margin. A copyright transmittal letter signed by all authors must accompany this (see "Instructions for Authors").

To the Editor.  —In the course of technologic advance, the bleeding bowl and the leech have been replaced by plasmapheresis. The rationale of each is much the same: to remove some "evil humor", or, in modern terms, presumed antibodies or immune complexes. The truth is, that in most instances plasmapheresis has been used without firm evidence of what the "evil humor" really is. Further studies of those human disorders for which plasmapheresis proves effective and of their animal models may clarify the nature of these circulating factors. Identification of specific antibodies and antigens

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