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September 1984

Autonomic Dysfunction and Sleep Apnea in Olivopontocerebellar Degeneration

Author Affiliations

From the Neurology Service, Veterans Administration Medical Center, Hines, Ill. Drs Chokroverty and Sachdeo are currently with the Veterans Administration Medical Center, Lyons, NJ, and the University of Medicine and Dentistry of New Jersey-Rutgers Medical School, New Brunswick. Dr Masdeu is currently with Montefiore Medical Center, New York.

Arch Neurol. 1984;41(9):926-931. doi:10.1001/archneur.1984.04050200032014

• We studied ten men with olivopontocerebellar degeneration. Our findings of the autonomic deficits as manifested by orthostatic hypotension, impaired Valsalva's response, abnormal findings on cold pressor and mental arithmetic tests, and plasma renin and norepinephrine abnormalities in some patients with olivopontocerebellar degeneration suggested a defective central control of the sympathetic nervous system. Five patients had sleep apnea. Autonomic dysfunction and sleep apnea in olivopontocerebellar degeneration may result from degenerative lesions in the cerebellum and the brain stem.

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