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September 1984

Chédiak-Higashi Syndrome: Neurologic Appearance

Author Affiliations

From the Child Evaluation and Treatment Program, Medical Center Rehabilitation Hospital (Dr Pettit and Ms Berdal), and the Department of Neurology, Grand Forks Clinic, Ltd (Dr Pettit), Grand Forks, ND.

Arch Neurol. 1984;41(9):1001-1002. doi:10.1001/archneur.1984.04050200111031

• A 25-year-old man was first seen with a neurologic disorder that resembled a spinocerebellar degeneration and parkinsonism. A peripheral smear revealed the characteristic peroxidase-positive panleukocytic granules associated with the Chédiak-Higashi syndrome. He did not have any associated oculocutaneous abnormalities. The Chédiak-Higashi syndrome may appear primarily with neurologic dysfunction and should be considered in a differential diagnosis of children and young adults first seen with a spinocerebellar degeneration or movement disorder.

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