• A 25-year-old man was first seen with a neurologic disorder that resembled a spinocerebellar degeneration and parkinsonism. A peripheral smear revealed the characteristic peroxidase-positive panleukocytic granules associated with the Chédiak-Higashi syndrome. He did not have any associated oculocutaneous abnormalities. The Chédiak-Higashi syndrome may appear primarily with neurologic dysfunction and should be considered in a differential diagnosis of children and young adults first seen with a spinocerebellar degeneration or movement disorder.
Pettit RE, Berdal KG. Chédiak-Higashi Syndrome: Neurologic Appearance. Arch Neurol. 1984;41(9):1001–1002. doi:10.1001/archneur.1984.04050200111031
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