• Although a single perinatal or postnatal event may be directly correlated to intraventricular hemorrhage (IVH) in some infants, in other infants IVH may be related to a series of insults. Asphyxia, hypotension, and a pressure-passive low cerebral blood flow (CBF) may lead to an infarction. Subsequent events known to cause sudden rises in the CBF may then produce a hemorrhage into damaged tissues. We report two cases of this proposed model for delayed hemorrhage into infarcted tissues, or late IVH. Both neonates were severely asphyxiated, and both experienced profound hypotension and a low CBF on the first postnatal day. Late IVH was found in both neonates; at 2 to 3 months of age, one neonate was found to have computed tomographic evidence for diffuse encephalomalacia, and the other neonate was noted to have an occipital porencephalic cyst.
Ment LR, Ehrenkranz RA, Duncan CC, Lange RC. Delayed Hemorrhagic Infarction: A Cause of Late Neonatal Germinal Matrix and Intraventricular Hemorrhage. Arch Neurol. 1984;41(10):1036–1039. doi:10.1001/archneur.1984.04050210034010
Neurology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.