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November 1984

Arthrogryposis Multiplex Congenita Occurring With Maternal Multiple Sclerosis

Author Affiliations

From the Moore Clinic, Division of Medical Genetics, Department of Medicine (Drs Livingstone and Sack), and the Departments of Pediatrics and Biological Chemistry (Dr Sack), Johns Hopkins University School of Medicine; and the John F. Kennedy Institute (Dr Sack), Baltimore.

Arch Neurol. 1984;41(11):1216-1217. doi:10.1001/archneur.1984.04050220118031

• All children of a mother with multiple sclerosis (MS) had increasing grades of congenital joint contractures without demonstrable neuromuscular disease. Two had talipes equinovarus, one had congenital hip subluxation, and the youngest had arthrogryposis multiplex congenita. Maternal MS may be causally related to the development of congenital joint contractures.

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