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February 1985

CSF Monoamine Metabolites in Movement Disorders and Normal Aging

Author Affiliations

From the Stanford Mental Health Clinical Research Center (Drs Stahl and Berger), the Nancy Pritzker Laboratory of Behavioral Neurochemistry (Drs Faull and Barchas), Department of Psychiatry and Behavioral Sciences, Stanford (Calif) University Medical Center, and the Schizophrenia Biologic Research Center, Veterans Administration Medical Center, Palo Alto, Calif (Drs Stahl and Berger).

Arch Neurol. 1985;42(2):166-169. doi:10.1001/archneur.1985.04060020080021

• We measured four monoamine metabolite levels in CSF before and after probenecid administration to normal controls and to patients with Huntington's disease (HD), dystonia, and tardive dyskinesia. We identified differences only for the dopamine metabolite homovanillic acid (HVA), which showed increased baseline values and decreased turnover in normal aging, but decreased baseline values and normal turnover in HD. These results suggest that dopamine neurons are linked both to normal aging and to HD and that CSF HVA studies can distinguish differences in the functioning of dopamine neurons in normal aging and HD.

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