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February 1985

Carbamazepine Toxicity Induced by Concurrent Erythromycin Therapy

Author Affiliations

From the Departments of Internal Medicine (Dr Carranco) and Neurology (Drs Kareus, Co, Peak, and Al-Rajeh), University of Louisville Health Sciences Center.

Arch Neurol. 1985;42(2):187-188. doi:10.1001/archneur.1985.04060020105023

• We describe a 41-year-old woman receiving carbamazepine for epilepsy, in whom concurrent erythromycin stearate administration led to carbamazepine toxicity, including inappropriate antidiuretic hormone syndrome. We review the literature on erythromycin-carbamazepine interaction and discuss the mechanism for such interaction.