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April 1985

Treatment of Multiple Sclerosis

Author Affiliations

Department of Neurology Albert Einstein College of Medicine 1300 Morris Park Ave Bronx, NY 10461

Arch Neurol. 1985;42(4):310. doi:10.1001/archneur.1985.04060040016005

To the Editor.  —The article by Khatri and co-workers in the July issue of the Archives1 will certainly provide hope for patients with multiple sclerosis. While some clinicians will find it incredible that patients with predominantly cerebral signs and symptoms can show improvement in their scores on the Kurtzke disability status scale from 9 to 0, 8 to 1, or 8 to 2, such improvement is not unprecedented. It is important to recall prior case reports of patients who, following brief therapy, made even more dramatic recoveries (Table).While the suppressor cell function assays, evoked potentials, and computed tomographic scans were not reported in these cases, the change in the disability status scale has been accepted by the majority of people in the western hemisphere for many years. Drs Khatri and colleagues have confirmed these earlier clinical trials.