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April 1985

Cholecystokinin and Neurotensin Gradients in Human CSF

Author Affiliations

From the Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke (NINCDS), Bethesda, Md (Drs Tamminga, LeWitt, and Chase), and the Maryland Psychiatric Research Center, University of Maryland, Baltimore (Dr Tamminga).

Arch Neurol. 1985;42(4):354-355. doi:10.1001/archneur.1985.04060040064013

• In successive samples of human lunbar CSF, concentrations of two neurally active peptides, cholecystokinin (CCK) and neurotensin (NT), were compared with levels of homovanillic acid (HVA), the major metabolite of dopamine. Although HVA values progressively increased between the first and 20th milliliter samples, no significant change occurred in the concentration of either peptide. Thus, lumbar CSF levels of CCK and NT, unlike levels of HVA, may not closely reflect amounts of these peptides in supraspinal CSF or brain.

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