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April 1985

Congenital Heart Defects in Live-born Children of Epileptic Parents

Author Affiliations

From the Departments of Neurology, Hvidovre and Gentofte Hospitals, University of Copenhagen (Dr Friis), and the Department of Clinical Neurophysiology and the Epilepsy Clinic, Odense Hospital, and Institute of Clinical Genetics, University of Odense (Denmark) (Dr Hauge).

Arch Neurol. 1985;42(4):374-376. doi:10.1001/archneur.1985.04060040084018

• In a study of congenital heart defects (CHD) in 2,461 live-born children of an unselected group of 979 male and 1,093 female epileptics, 18 children with CHD were recorded; eight had epileptic fathers and 10 epileptic mothers. The prevalence of CHD does not differ significantly from that of the background population. Many different CHD types were recorded with no single defect being predominant. Likewise, no association with a specific type of anticonvulsant treatment was noted. The fact that the prevalence of CHD among children of male and female epileptics and of the background population was similar supports the view that antiepileptic treatment is no major factor in the etiology of CHD in the offspring of epileptics.

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