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May 1985

Incidence of Seizures With Tricyclic and Tetracyclic Antidepressants

Author Affiliations

From the Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Md, and the Neurology Service, Walter Reed Army Medical Center, Washington, DC.

Arch Neurol. 1985;42(5):480-481. doi:10.1001/archneur.1985.04060050082013

• One hundred eighty-six depressed psychiatric inpatients were seen at our institution during 1982. Forty-five of these patients were treated with tricyclic antidepressants, 32 received maprotiline hydrochloride, a tetracyclic compound, 20 received other medications, and 82 received no drug treatment. One patient in the tricyclic group (2.2%) and five patients in the maprotiline group (15.6%) developed seizures. In four patients the seizure followed the institution of maprotiline therapy by less than three weeks. These data indicate that depressed patients taking the tetracyclic drug maprotiline are at risk for developing epileptic seizures.

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