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Article
June 1985

Insignificant Risk for Arthrogryposis Multiplex Congenita

Author Affiliations

Department of Medical Genetics University of British Columbia 224 Westbrook Bldg 6174 University Blvd Vancouver, British Columbia, Canada V6T 1W5

Arch Neurol. 1985;42(6):516. doi:10.1001/archneur.1985.04060060014005
Abstract

To the Editor.  —I read with interest the article by Livingstone and Sack1 on arthrogryposis multiplex congenita (AMC) occurring with maternal multiple sclerosis (MS). The authors suggest that surveillance of pregnancies with maternal MS should allow improved assessment of the risks for AMC.The MS Clinic of the Health Sciences Centre Hospital, University of British Columbia, Vancouver, was established in September 1980. Since its inception I have routinely taken detailed genetic histories for all MS patients attending the clinic. Data on the outcome of all pregnancies included information on congenital malformations among the offspring of patients. To date, genetic histories have been taken for a total of 765 persons (510 women and 255 men) with a diagnosis of clinically definite or probable MS according to modified Schumacher et al criteria.2 Among the women, 31.6% (161/510) had at least one pregnancy after the onset of MS.

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