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July 1985

Vancomycin Treatment for Enterococcal Meningitis

Author Affiliations

From the Divisions of Clinical Pharmacy (Dr Barriere) and Infectious Diseases (Drs Lutwick, Jacobs, and Conte), University of California, San Francisco. Dr Lutwick is now with the Maimonides Medical Center, Brooklyn, NY.

Arch Neurol. 1985;42(7):686-688. doi:10.1001/archneur.1985.04060070076020

• Although clinical disease due to enterococcus is common, there has been only limited experience in the treatment of central nervous system infections by this pathogen. In particular, there have been few reports regarding the treatment of such infections in the penicillin-allergic individual. We present two cases of meningitis due to enterococci, including one case with a brain abscess, in patients with strong histories of penicillin sensitivity. We treated these patients with vancomycin hydrochloride and an aminoglycoside. Vancomycin with an aminoglycoside seems to be a reasonable treatment for enterococcal central nervous system infections.

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