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July 1985

Intraneuronal Accumulation of Myeloma Proteins

Author Affiliations

From the Neurosurgical Service (Dr Borges) and Department of Neurology (Dr Busis), Massachusetts General Hospital, and the Department of Neuroscience, Children's Hospital Medical Center (Dr Borges), Boston.

Arch Neurol. 1985;42(7):690-694. doi:10.1001/archneur.1985.04060070084021

• We studied a patient with multiple myeloma who had immunologically identfied myeloma light chain proteins within neurons projecting beyond the blood-brain barrier, but not within intrinsic neurons of the spinal cord, brain stem, and cerebral cortex. There was a possibility that these myeloma light chain proteins or their immunologically recognizable fragments were transported intra-axonally by human peripheral nerves. Myeloma light chain proteins were also identified within cerebellar Purkinje's neurons. This labeling may have been secondary to transport from cerebrospinal fluid.

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