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August 1985

Alternate-Day Clonazepam Treatment of Intractable Seizures

Author Affiliations

From the Division of Pediatric Neurology, University of Minnesota Medical School, Minneapolis, and the Epilepsy Program for Children, Gillette Children's Hospital, St Paul.

Arch Neurol. 1985;42(8):787-788. doi:10.1001/archneur.1985.04210090051014

• Several investigations have demonstrated a reduction in benzodiazepine receptor binding after long-term exposure to this class of drugs. Such receptor alterations may contribute to the decreased efficacy of benzodiazepines in the management of convulsive disorders. To minimize receptor alterations, several patients with intractable seizures received alternate-day clonazepam therapy, resulting in improved seizure control. The favorable clinical responses suggest that alternative methods of benzodiazepine administration may circumvent receptor subsensitivity resulting from prolonged drug treatment.

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