• Several investigations have demonstrated a reduction in benzodiazepine receptor binding after long-term exposure to this class of drugs. Such receptor alterations may contribute to the decreased efficacy of benzodiazepines in the management of convulsive disorders. To minimize receptor alterations, several patients with intractable seizures received alternate-day clonazepam therapy, resulting in improved seizure control. The favorable clinical responses suggest that alternative methods of benzodiazepine administration may circumvent receptor subsensitivity resulting from prolonged drug treatment.
Sher PK. Alternate-Day Clonazepam Treatment of Intractable Seizures. Arch Neurol. 1985;42(8):787–788. doi:10.1001/archneur.1985.04210090051014
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