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August 1985

Adenovirus Type 2 Encephalitis and Concurrent Epstein-Barr Virus Infection in an Adult Man

Author Affiliations

From the Division of Infectious Diseases, Department of Medicine (Drs West and Parker), the Department of Medical Medical Technology (Dr Papasian), and the Department of Pediatrics (Dr Park), State University of New York at Buffalo, School of Medicine.

Arch Neurol. 1985;42(8):815-817. doi:10.1001/archneur.1985.04210090083023

A 30-year-old bisexual male prisoner with a historyy of intravenous drug abuse manifested encephalitis. Adenovirus type 2 was isolated from brain tissue obtained by a biopsy and there was a concurrent fourfold rise in the antibody titer. In addition, an initial negative result from a slide test for infectious mononucleosis heterophil antibodies (Monospot) test converted to positive and there was an increase in the IgG antibodyy titer to Epstein-Barr virus (EBV) viral capsid antigen. Although he was anergic to skin test antigens, T-cell subsets and lymphocyte transformation study results were normal. This case demonstrated a rare adenovirus encephalitis with a simultaneous EBV infection in a patient at risk for acquired immunodeficiency syndrome, who had minimal evidence of T-cell deficiency.

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