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September 1985

Involvement of the Nervous System in Hairy Cell Leukemia

Author Affiliations

Department of Pathology
Department of Hematology Henri Mondor Hospital 94010 Créteil Cédex France

Arch Neurol. 1985;42(9):839. doi:10.1001/archneur.1985.04060080017005

To the Editor.  —We read with interest the article by Kimmel et al.1 These authors claimed that, as far as they knew, no well-documented clinicopathologic study of central nervous system infiltration in hairy cell leukemia had been reported. In the 108 cases that they reviewed, neurologic complications developed in eight cases and no case of direct infiltration of the central nervous system was observed. Our purpose is to draw attention to a clinicopathologic case of hairy cell leukemia with infiltration of the brain, which we reported in a French journal several years ago.2

Report of a Case.  —A 35-year-old man was admitted with progressive weakness and splenomegaly. The blood examination, myelogram, and bone marrow biopsy led to a diagnosis of splenic and medullary histiolymphocytosis. Four months later, the patient developed an infectious syndrome and a meningeal syndrome. The cerebrospinal fluid was normal. One month later, the patient

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