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October 1985

Usefulness of Heparin in Initial Management of Patients With Recent Transient Ischemic Attacks

Author Affiliations

From the Department of Neurology, University of Iowa, Iowa City.

Arch Neurol. 1985;42(10):960-962. doi:10.1001/archneur.1985.04060090042011

• We evaluated the efficacy of short-term intravenous heparin therapy in 74 patients with recent transient ischemic attacks (TIAs). The patients were treated after hospitalization until operation or long-term medical treatment was instituted. Heparin was given in a continuous infusion to maintain an activated partial thromboplastin time of 11/2 to 21/2 times control values. During the treatment period, 12 patients (16.2%) had recurrent TIAs and five (6.8%) had cerebral infarction. Bleeding complications occurred in nine patients (12.2%). In this limited series, heparin did not prevent recurrent TIAs or cerebral infarction among high-risk patients with recent TIAs.

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