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Article
October 1985

Usefulness of Heparin in Initial Management of Patients With Recent Transient Ischemic Attacks

Author Affiliations

From the Department of Neurology, University of Iowa, Iowa City.

Arch Neurol. 1985;42(10):960-962. doi:10.1001/archneur.1985.04060090042011
Abstract

• We evaluated the efficacy of short-term intravenous heparin therapy in 74 patients with recent transient ischemic attacks (TIAs). The patients were treated after hospitalization until operation or long-term medical treatment was instituted. Heparin was given in a continuous infusion to maintain an activated partial thromboplastin time of 11/2 to 21/2 times control values. During the treatment period, 12 patients (16.2%) had recurrent TIAs and five (6.8%) had cerebral infarction. Bleeding complications occurred in nine patients (12.2%). In this limited series, heparin did not prevent recurrent TIAs or cerebral infarction among high-risk patients with recent TIAs.

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