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December 1985

Severe Multicore Disease Associated With Reaction to Anesthesia

Author Affiliations

From the Department of Physical Medicine and Rehabilitation, Children's Hospital National Medical Center, Washington, DC (Drs Koch and Eng); and the Department of Neurology, University of Tennessee Center for the Health Sciences, Memphis (Drs Bertorini and Boehm).

Arch Neurol. 1985;42(12):1204-1206. doi:10.1001/archneur.1985.04060110086024

• Multicore disease is a nonprogressive myopathy. To our knowledge, in all previous cases, the clinical course has been benign with no deaths attributed to it. We describe a patient who presented as a floppy baby and remained weaker throughout his life than any other patients previously described. Biopsy findings were characteristic of multicore disease. However, at age 21/2 years, our patient developed congestive heart failure that was easily controlled with digitalis and diuretics. Shortly after cardiac catheterization, the patient developed a high, unexplained fever and died 26 hours later despite aggressive attempts at resuscitation. Therefore, patients with multicores in skeletal muscle may have severe weakness and may also have a predisposition to complications subsequent to anesthesia.

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