To the Editor.—
Several reports, most recently by Bartfeld et al,1 indicate possible HLA system involvement in amyotrophic lateral sclerosis (ALS). For example, Bartfeld and co-workers1 found a trend toward increased frequency of HLA-Bw35, in agreement with Kott et al.2 What has not been emphasized is that statistical trends are not important when other studies find different trends. For example, Antel et al3 found increases of HLA-A3 in rapidly progressive ALS and HLA-Bw12 in ALS with slower courses. Kott et al2 also found a significant increase in HLA-A3; they stated that their HLA-Bw35 increase was not significant. Jokelainen et al4 found an increased incidence of HLA-Bw40 in ALS cases with slower courses. Behan and colleagues5 report
Norris FH, Terasaki PI, Henderson B. HLA Typing in Amyotrophic Lateral Sclerosis. Arch Neurol. 1986;43(1):7. doi:10.1001/archneur.1986.00520010007002
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