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January 1986

Schilder's (1912) Disease: Total Cerebral Blindness due to Acute Demyelination

Author Affiliations

From the Departments of Ophthalmology (Drs Sedwick, Klingele, and Burde), Neurology and Neurological Surgery (Dr Burde), Pathology (Dr Fulling), and Radiology (Dr Gado), Washington University School of Medicine, St Louis. Dr Sedwick is now in private practice in Orlando, Fla.

Arch Neurol. 1986;43(1):85-87. doi:10.1001/archneur.1986.00520010079027

• A 51-year-old woman became blind from involvement of both occipital lobes with a confluent lesion demonstrated by computed tomographic scan. Biopsy showed demyelination consistent with Schilder's 1912 variant of diffuse sclerosis. No cytoplasmic inclusions were found on electron microscopy.

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