[Skip to Content]
[Skip to Content Landing]
February 1986

Pharmacologic Treatment of Parkinsonian Tremor

Author Affiliations

From the Departments of Neurology, Loyola University School of Medicine, Chicago, and Hines (Ill) Veterans Administration Hospital.

Arch Neurol. 1986;43(2):126-127. doi:10.1001/archneur.1986.00520020020009

• The relative efficacy of trihexiphenidyl hydrochloride, amantadine hydrochloride, and low-dose carbidopa-levodopa in reducing parkinsonian tremor was investigated using objective techniques. Trihexiphenidyl and carbidopa-levodopa decreased tremor by greater than 50%. Some patients responded to one drug but not to the other. Amantadine decreased tremor less than 25%. Monotherapy with trihexiphenidyl or carbidopa-levodopa should be the initial treatment for the tremor of Parkinson's disease.