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February 1986

Cerebrospinal Fluid Neuron-Specific Enolase Is Reduced in Alzheimer's Disease

Author Affiliations

From the Section on Brain Aging and Dementia, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Md (Drs Cutler and Kay and Ms Burg), and the Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Md (Dr Marangos). Dr Kay is presently with the Department of Geriatrics, Mount Sinai School of Medicine, New York.

Arch Neurol. 1986;43(2):153-154. doi:10.1001/archneur.1986.00520020047017

• Neuron-specific enolase (NSE), a glycolytic enzyme enolase found in brain, was examined in the cerebrospinal fluid and serum of 30 patients with presumptive Alzheimer's disease (AD) and of 13 healthy controls and evaluated as a measure of neuronal functional activity associated with AD. The cerebrospinal fluid NSE levels of patients with AD were significantly reduced and serum NSE levels were significantly increased from controls. Cerebrospinal fluid NSE levels may be representative of central nervous syntem cell loss or a decrease in neuronal functional activity associated with AD.

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