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February 1986

Immunosuppressive Drug Therapy in Myasthenia Gravis

Author Affiliations

From the Departments of Neurology, Baylor College of Medicine and the Veterans Administration Hospital, Houston.

Arch Neurol. 1986;43(2):155-156. doi:10.1001/archneur.1986.00520020049018

• We reviewed the records of 37 patients with myasthenia gravis treated with azathioprine (n = 10) or cyclophosphamide (n = 27). All patients had received prednisone and anticholinesterase therapy, and most had undergone thymectomy prior to immunosuppressive therapy. Thirty patients (81%) responded to treatment. Both azathioprine and cyclophosphamide were found to be effective in the treatment of myasthenia gravis. The degree of improvement was more pronounced in patients with thymoma.