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March 1986

Laterality and Neurochemical Findings in Parkinson's Disease

Author Affiliations

Department of Neurology University of Turin School of Medicine Via Cherasco 15 10126 Turin Italy

Arch Neurol. 1986;43(3):207. doi:10.1001/archneur.1986.00520030003001

To the Editor.  —In their recent article, Direnfeld and co-workers1 suggested a possible relationship between the side of greater involvement and the cerebrospinal fluid (CSF) neurochemical findings in Parkinson's disease (PD). Principally, the authors stressed that PD patients affected on the right side of the body (PDR) show significantly lower homovanillic acid (HVA) levels in the CSF than the PD patients affected on the left side (PDL). This finding was interpreted as evidence of functional/structural asymmetries of dopaminergic pathways in the central nervous system (CNS). However, in our studies on CNS degenerative diseases, which included the evaluation of CSF monoamine metabolite levels, we were not able to reproduce the results of the quoted authors.

Subjects and Methods.  —Forty subjects were selected for study and divided into four groups: healthy controls (15 subjects), PDR (five subjects), PDL (five subjects), and dementia of Alzheimer's type (DAT) (15 subjects). All were volunteers and gave their

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