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March 1986

Differential Patterns of Memory Loss Among Patients With Alzheimer's Disease, Huntington's Disease, and Alcoholic Korsakoff's Syndrome

Author Affiliations

From the Department of Anatomy, Boston University School of Medicine (Dr Moss); Departments of Psychiatry (Drs Moss and Albert) and Neurology (Dr Albert), Massachusetts General Hospital and Harvard Medical School, Boston; Psychology Service, San Diego Veterans Administration Medical Center (Dr Butters); Department of Psychiatry, University of California, San Diego (Dr Butters); and Department of Psychology, University of Iowa, Iowa City (Ms Payne).

Arch Neurol. 1986;43(3):239-246. doi:10.1001/archneur.1986.00520030031008

• Patients with Huntington's disease (HD), alcoholic Korsakoff's syndrome (KS), and Alzheimer's disease (AD) were compared with normal control subjects on a task designed to assess recognition memory for different classes of stimuli: spatial, verbal, color, pattern, and facial. In addition, recall of verbal stimuli was assessed at two delay intervals. On recognition testing, AD and KS patients were impaired on each of the five stimulus conditions. However, HD patients, though impaired on four of the recognition conditions, were unimpaired when verbal stimuli were used. On recall testing, the AD, HD, and KS groups were equally impaired at the shorter delay (15 s). However, at the longer delay (two minutes), the KS and HD patients, though still impaired relative to the normal control group, performed significantly better than the AD group.

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