• Ampicillin trihydrate aggravated the symptoms of two myasthenic patients. One patient had severe temporary weakness after an ampicillin sodium challenge. Ampicillin increased the preexisting electrical decrement in three rabbits with experimental autoimmune myasthenia gravis while the drug had no deleterious effects in less affected or normal animals. Myasthenic patients receiving ampicillin should be closely monitored for possible acute exacerbations.
Argov Z, Brenner T, Abramsky O. Ampicillin May Aggravate Clinical and Experimental Myasthenia Gravis. Arch Neurol. 1986;43(3):255–256. doi:10.1001/archneur.1986.00520030045010
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: