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May 1986

Involvement of the Nervous System in Hairy-Cell Leukemia

Author Affiliations

Department of Pathology
Department of Haematology Henri Mondor Hospital 94010 Créteil Cédex, France

Arch Neurol. 1986;43(5):432. doi:10.1001/archneur.1986.00520050012010

To the Editor.  —We read with interest the article on "Neurologic Complications of Hairy-Cell Leukemia" by Kimmel et al.1 These authors claim that, as far as they know, no welldocumented clinicopathologic study of central nervous system infiltration by hairy-cell leukemia has been reported. Of the 108 cases that these authors reviewed, neurologic complications developed in eight cases and no case of direct infiltration of the central nervous system was observed. Our purpose is to draw attention to a clinicopathologic case of hairy-cell leukemia with infiltration of the brain that we reported in a French journal several years ago.2

Report of a Case.  —A 35-year-old man was admitted to a hospital with progressive weakness and splenomegaly. The blood film, the myelogram, and the bone marrow biopsy led to a diagnosis of splenic and medullary histiolymphocytosis. Four months later, the patient developed an infectious syndrome and a meningeal syndrome.

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