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May 1986

Chronic Human Colchicine Neuropathy and Myopathy

Author Affiliations

From the Departments of Neurology (Drs Riggs, Gutmann, and Crosby), Pathology (Dr Schochet), and Medicine (Dr DiBartolomeo), West Virginia University School of Medicine, Morgantown.

Arch Neurol. 1986;43(5):521-523. doi:10.1001/archneur.1986.00520050091033

• A 43-year-old woman who indiscriminately took colchicine for five years developed a progressive multisystem syndrome that included severe axonal neuropathy and a pathologically striking myopathy. The neuropathy and myopathy were similar to experimental animal colchicine-induced neuromuscular toxicity.

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