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June 1986

Relapsing Central and Peripheral Demyelinating Diseases: Unusual Pathologic Features

Author Affiliations

From the Charles S. Kubik Neuropathology Laboratory, Department of Neurology (Dr Ropper) and the James Homer Wright Pathology Laboratories (Drs Dickersin, Harris, and Ferry), Massachusetts General Hospital, and Harvard Medical School (Drs de la Monte and Richardson), Boston.

Arch Neurol. 1986;43(6):626-629. doi:10.1001/archneur.1986.00520060084027

• We treated a patient who had a demyelinating peripheral neuropathy and a central nervous system inflammatory demyelinating disease. The unusual pathologic feature of dense infiltrates of atypical macrophages was observed in many areas of the brain; otherwise the process had several features in common with either multiple sclerosis or chronic relapsing experimental allergic encephalomyelitis. The illness followed "swineflu" inoculation; exacerbation followed pneumococcal vaccination.

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