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July 1986

What Is the Best Treatment for Reye's Syndrome?

Author Affiliations

From the Departments of Neurosciences and Pediatrics, University of California School of Medicine, La Jolla.

Arch Neurol. 1986;43(7):729. doi:10.1001/archneur.1986.00520070083023

• the precise origin of Reye's syndrome is unknown, therapeutic approaches to the disease have three major goals: intensive supportive care, correction of identifiable metabolic abnormalities, and control of intracranial pressure (ICP).1

For mild cases (stages I and II), the patient should be observed closely in a pediatric intensive care unit (such patients are subject to rapid and sudden deterioration in neurologic status) and treated with intravenous hypertonic (10% to 15%) glucose solutions at normal maintenance volumes. There is evidence that administration of hypertonic glucose solution to patients in the early stages may prevent disease progression.2 If the disease progresses to stage III or worse, more aggressive therapy is necessary. The following recommendations are for treatment of patients with severe Reye's syndrome (stages III through V).

INTENSIVE SUPPORTIVE CARE  Children with Reye's syndrome are subject to hyperthermia, even in the absence of detectable infection, and to sudden respiratory