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October 1986

Brain Asymmetries in Situs Inversus: A Case Report and Review of the Literature

Author Affiliations

From the Department of Medicine, University of Washington, Seattle.

Arch Neurol. 1986;43(10):1083-1084. doi:10.1001/archneur.1986.00520100087021

It is well known that the brain is an asymmetric organ and that the direction of brain asymmetries in humans is consistent throughout most of the population. Most individuals are right-handed with left hemisphere dominance for speech, and postmortem1 and radiologic2 studies have suggested an anatomic basis for such asymmetries. A number of theories have been proposed in recent years to explain the biologic origin of brain asymmetries and why certain individuals deviate from the expected pattern.3-8

The relationship postulated between brain asymmetries and other asymmetries found in the human body is a major point of difference among these theories. Corballis and Morgan have proposed that both visceral and brain asymmetries are the result of a single embryologic leftright gradient found in the developing oocyte.3,4 In contrast, Annett5 has proposed that brain asymmetries and asymmetries of the other internal organs are inherited independently. These

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