[Skip to Content]
[Skip to Content Landing]
Article
November 1986

Quantitative Cerebrospinal Fluid IgG Measurements as a Marker of Disease Activity in Multiple Sclerosis

Author Affiliations

From the Departments of Neurology (Drs Caroscio, Cohen, and Yahr), Pathology and Medicine (Drs Kochwa and Makuku), and Biomathematical Sciences (Dr Sacks), Mount Sinai School of Medicine, New York.

Arch Neurol. 1986;43(11):1129-1131. doi:10.1001/archneur.1986.00520110029009
Abstract

• The value of various parameters of reporting quantitative cerebrospinal fluid (CSF) IgG levels to indicate disease activity in 34 patients with clinically definite multiple sclerosis was examined. IgG alone correlated significantly with increasing degree of disability and increasing number of clinical central nervous system lesions. There was also a trend toward higher mean IgG levels when the course was relapsing and progressive as opposed to progressive or relapsing. For the IgG index, the relationships were the inverse of that noted with IgG alone. IgG-albumin ratio and IgG synthetic rate did not correlate significantly with course, number of CNS lesions, or degree of disability, and there was no statistically significant relationship between any parameter of reporting quantitative CSF IgG and age, duration of diesase, history of recent exacerbation, or area of first involvement in the nervous system. We conclude that although newer methods of reporting CSF IgG elevations in multiple sclerosis are more sensitive and some of them, more specific, in confirming a diagnosis than CSF IgG alone, this parameter remains the best marker of disease activity in individual patients.

×