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January 1987

The Electroencephalogram in Alzheimer-Type Dementia: A Sequential Study Correlating the Electroencephalogram With Psychometric and Quantitative Pathologic Data

Author Affiliations

From the Department of Clinical Neurological Sciences, University Hospital (Drs Rae-Grant, Blume, and Hachinski), and the Department of Education and Research, London Psychiatric Hospital (Ms Lau, and Drs Fisman and Merskey), London, Ontario.

Arch Neurol. 1987;44(1):50-54. doi:10.1001/archneur.1987.00520130042015

• As part of a longitudinal cohort study of dementia, 139 patients with Alzheimer's disease (dementia of the Alzheimer type, senile dementia of the Alzheimer type, and mixed type [ischemic score, 4 to 7]) and 148 age-matched control subjects were evaluated for electroencephalographic (EEG) abnormalities and their evolution. Electroencephalograms were significantly different in the two groups; EEGs worsened overall in the two groups during a period of one to four years, but most subjects showed no alteration in their EEGs. Some patients showed improvement in their EEG findings during the follow-up period. A strong correlation between EEG grade and psychometric scores was consistently found over sequential studies. In a subgroup of patients on whom autopsies were performed, morphometric neuron loss correlated significantly with EEG severity.

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