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February 1987

Diagnostic Pathology of Skeletal Muscle and Nerve

Author Affiliations

Rochester, NY

Arch Neurol. 1987;44(2):127. doi:10.1001/archneur.1987.00520140003002

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This book is a conveniently sized, readable introduction to the pathology of nerve and skeletal muscle. The first chapter outlines the techniques of muscle biopsy and specimen preparation, reviews the histology of normal muscle, and includes a practical section describing the usefulness of the various histologic stains. The next several chapters discuss the pathologic changes seen in muscle biopsy specimens, including changes seen with denervating disorders, inflammatory myopathies, muscular dystrophies, myotonic disorders, metabolic myopathies, and congenital myopathies. Inclusion body myositis and the mitochondrial myopathies, two relatively new pathologic entities, are nicely discussed. The remaining four chapters cover the histopathology of peripheral nerve, a topic often omitted in neuromuscular texts. This section briefly discusses the pathologic findings seen in inflammatory, neoplastic, metabolic, toxic, and hereditary neuropathies.

This book is well organized and extensively illustrated with high quality light and electron microscopic photomicrographs that are amazingly free from artifact. Concise clinical discussions

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