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February 1987

Subcortical Dementia

Author Affiliations

Neurological Institute 710 W 168th St New York, NY 10032

Arch Neurol. 1987;44(2):129-130. doi:10.1001/archneur.1987.00520140005006

To the Editor.  —Despite controversy, the concept of subcortical dementia is endorsed by many, and enjoys much space in the literature. The remarkable fact is that only a few investigations have ever examined the issue,1,2 even though it is the topic of numerous reviews3-7 and a single report.8 As Mark Twain9 once wrote, "There is something fascinating about science. One gets such wholesome returns of conjecture out of such a trifling investment of fact."The article by Huber et al2 is an improvement over the usual description of subcortical dementia in a single disease with speculation about its probable difference from other diseases with dementia. Unfortunately, this study also has its problems. Most obvious is the failure to equate severity of dementia in the two patient groups (dementia of the Alzheimer type [DAT] and Parkinson's disease [PD]) before analysis of the neuropsychological test performance. The

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