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March 1987

The Use of Apolipoprotein CII as a Genetic Marker for Myotonic Dystrophy

Author Affiliations

From the Neurology Service, Veterans Administration Medical Center (Dr Bird and Ms Lipe), and the Department of Medicine (Neurology and Medical Genetics), University of Washington Medical School (Drs Bird, Schellenberg, and Deeb), Seattle, and the Department of Biostatistics, the School of Public Health, University of Michigan, Ann Arbor (Dr Boehnke).

Arch Neurol. 1987;44(3):273-275. doi:10.1001/archneur.1987.00520150029015

• In five families we have confirmed the close linkage between the genes for myotonic dystrophy and apolipoprotein Cll. The total maximum lod (log of the odds) score was 3.32 at 0 recombination. We demonstrate that the use of a Ban I restriction site polymorphism for apolipoprotein Cll adds additional useful information when combined with the more commonly used Taq I polymorphism. The potential practical clinical use of these markers for the prenatal diagnosis of myotonic dystrophy is demonstrated.

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