• In five families we have confirmed the close linkage between the genes for myotonic dystrophy and apolipoprotein Cll. The total maximum lod (log of the odds) score was 3.32 at 0 recombination. We demonstrate that the use of a Ban I restriction site polymorphism for apolipoprotein Cll adds additional useful information when combined with the more commonly used Taq I polymorphism. The potential practical clinical use of these markers for the prenatal diagnosis of myotonic dystrophy is demonstrated.
Bird TD, Boehnke M, Schellenberg GD, Deeb SS, Lipe HP. The Use of Apolipoprotein CII as a Genetic Marker for Myotonic Dystrophy. Arch Neurol. 1987;44(3):273–275. doi:10.1001/archneur.1987.00520150029015
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