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Article
March 1987

Cerebrospinal Myelin Basic Protein in Multiple SclerosisIdentification of Two Groups of Patients With Acute Exacerbation

Author Affiliations

From the Department of Neurology, Hôpital Henri Mondor, Creteil, France (Drs Martin-Mondière, Cèsaro, Carydakis, and Degos), and the Department of Neurochemistry, Hôpital de la Salpêtrière, Paris (Drs Jacque and Delassalle).

Arch Neurol. 1987;44(3):276-278. doi:10.1001/archneur.1987.00520150032016
Abstract

• The myelin basic protein concentration in the cerebrospinal fluid (CSF) of 125 patients with multiple sclerosis was measured using a radioimmunoassay technique with a detection level of 200 pg/mL and was correlated with the clinical course of the disease. Myelin basic protein was detected in the CSF of some patients with an active progressive form of the disease and in the CSF obtained during exacerbations with the presence of signs or symptoms not previously experienced by the patient (26 of 29 cases were positive during the period of maximal symptoms). Myelin basic protein was not detected in any patient with an inactive or slowly progressive form of the disease, nor in any patient during exacerbations with only recurrence of old signs or symptoms. These results are consistent with the hypothesis that the two clinical forms of exacerbation defined above may be associated respectively with the absence or presence of an acute demyelination.

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