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April 1987

Cholinesterases in Cerebrospinal Fluid: A Longitudinal Study in Alzheimer Disease

Author Affiliations

From the Department of Medicine, Division of Neurology (Dr Elble), and the Department of Pharmacology (Dr Giacobini), Southern Illinois University School of Medicine, Springfield; and the Department of Cell Biology, University of Rome (Dr Scarsella).

Arch Neurol. 1987;44(4):403-407. doi:10.1001/archneur.1987.00520160041012

• We measured acetylcholinesterase (AChE) and butyrylcholinesterase activities in the lumbar cerebrospinal fluid (CSF) of 39 patients with dementia of Alzheimer type and 21 age-matched controls. The mean lumbar CSF AChE activity in our patients did not differ significantly from that of controls. The 7S and 11S molecular forms were also unchanged. When CSF was analyzed at six-month intervals, there was no significant decline in AChE activity over a span of 12 months. Our results and those of previous studies demonstrate that CSF AChE is not a useful diagnostic marker of Alzheimer disease.

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