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June 1987

Clobazam for Refractory Epilepsy

Author Affiliations

Department of Neurology King's College Hospital Denmark Hill London SE5, England

Arch Neurol. 1987;44(6):578. doi:10.1001/archneur.1987.00520180004002

To the Editor.  —We agree with Schmidt et al1 that clobazam therapy can have a dramatic effect on seizure control in some patients with chronic drug-resistant complex partial seizures, but that unfortunately tolerance develops in over 50% of such responders. We have recently attempted to answer the question posed by Schmidt et al1 as a result of their study, ie, the need to identify and select those patients who are likely to obtain sustained dramatic benefit from clobazam therapy.Clobazam was given as add-on therapy in doses varying between 10 and Comparison of Responders and Nonresponders to Clobazam Therapy Reduction in Seizures No >90% <90% Response No. 8 30 7 Mean age, y 40.5 29.9 23.3 Duration of epilepsy, y 25.1 21.9 15.4 Seizure frequency before clobazam treatment, No. per mo 10.5 14.0 11.8 Seizure type Partial alone 3 3 0 Partial with 2° generalization 5 27 7

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