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July 1987

Valproic Acid Loading During Intensive Monitoring

Author Affiliations

From the Department of Neurology and Comprehensive Epilepsy Program, University of Minnesota, Minneapolis (Drs Rosenfeld, Leppik, Gates, and Mireles), and St Paul Ramsey Medical Center, St Paul, Minn (Dr Leppik).

Arch Neurol. 1987;44(7):709-710. doi:10.1001/archneur.1987.00520190021010

• Of 35 patients who had generalized tonic-clonic seizures during antiepileptic drug therapy withdrawal, "loading" with valproic acid was effective in limiting these seizures in 32 patients. A loading dose of approximately 12.5 mg/kg was used. This dose resulted in valproic acid levels between 284 and 458 μmol/L (41 and 66 mg/L) 1.5 hours after "loading" in six of the eight patients in whom serum concentrations were measured.

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