—As Professor Stevens points out, our data1,2 do not determine whether the reproductive endocrine disorders that were found to be more common in our subjects than in the general population are specifically associated with temporal lobe epilepsy or may occur with other forms of epilepsy. While Toone et al3,4 assessed patients with various forms of epilepsy in their two investigations that, for the first time, significantly related epilepsy, reproductive endocrine abnormalities, and sexual dysfunction, they presented the results of pooled data that do not differentiate among the various forms of epilepsy. Moreover, since they compared treated, but not untreated, epileptic patients with normal control subjects, one cannot be certain as to whether the treatment, the epilepsy, or both were critical to the association with reproductive endocrine abnormalities and hyposexuality.Is temporal lobe involvement essential to the reproductive endocrine and sexual changes found among epileptic patients? To answer this
Herzog A, Schomer D. Temporal Lobe Epilepsy: Response to Endocrine Dysfunction?-Reply. Arch Neurol. 1987;44(8):796–797. doi:10.1001/archneur.1987.00520200004004
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.