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August 1987

Neuropsychological Features of Early and Late-Onset Alzheimer's Disease-Reply

Author Affiliations

University of Colorado Health Sciences Center Denver, CO 80262

Arch Neurol. 1987;44(8):797-798. doi:10.1001/archneur.1987.00520200005006

In Reply.  —Our study was undertaken primarily to test the hypothesis of Seltzer and Sherwin1 regarding the greater degree of language impairment in younger patients with Alzheimer's disease (AD). The observation that significant linguistic disturbances can occur in this group is not new2,3 and, indeed, Alzheimer's first case was a woman in her 50s who had a language deficit in addition to memory loss and personality change.4 Our results provide qualified support for Seltzer and Sherwin's claim and further suggest that older patients with AD may suffer more from visuoconstructional deficits. The tests on which we base these preliminary conclusions—the Aphasia Screening Test (AST) and the Spatial Relations measure—have been shown in previous work to be sensitive to left and right hemisphere dysfunction, respectively.5The three studies cited by Koss and Friedland are of interest, but we are uncertain of their significance. Loring and Largen6 reported greater

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