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August 1987

HLA-DR2 and Narcolepsy

Author Affiliations

From the Departments of Neurology (Drs Kramer and Dinner) and Immunopathology (Drs Braun and Zachary, and Mr Teresi), Cleveland Clinic Foundation.

Arch Neurol. 1987;44(8):853-855. doi:10.1001/archneur.1987.00520200055019

• Tissue typing was performed on 14 narcoleptics as defined by both strict sleep laboratory and clinical criteria. Six of these patients were blacks from North America, a race underrepresented in previous studies. All patients were HLA-DR2-antigen positive and had the same HLA-DR2 subtype. Clinical severity of disease was not correlated with HLA-DR2 heterozygosity or (putative) homozygosity. This study confirms that the extremely high association between HLA-DR2 and narcolepsy holds across comparisons of the three races studied to date when both clinical and sleep laboratory data are used. The presence or absence of HLA-DR2 in patients presenting with hyper-somnolence may help support or exclude, respectively, a diagnosis of idiopathic narcolepsy.

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