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September 1987

Improvement in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Following γ-Globulin Infusion

Author Affiliations

Department of Neurology University Hospital Dijkzigt Dr Molewaterplein 40 3015 GD Rotterdam, the Netherlands

Arch Neurol. 1987;44(9):897-898. doi:10.1001/archneur.1987.00520210005005

To the Editor.  —Albala and his colleagues reported the improvement of neurologic function in one patient with a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) following γ-globulin infusion.1 The rationale for this treatment was the beneficial treatment response following γ-globulin infusion in patients with idiopathic thrombocytopenic purpura and myasthenia gravis.The rationale could also have been the reported beneficial response in patients with CIDP, since Vermeulen et al2 described improvement after fresh-frozen plasma and γ-globulin infusion in patients with CIDP.In this report,2 13 of 17 patients with CIDP improved after infusion of fresh-frozen plasma. Nine patients had γ-globulin infusions, and eight patients improved. The first signs of improvement were seen within eight days of the onset of treatment. None of these patients had spontaneous remissions for two months before these infusions, and none had immunosuppressive treatment during the infusions.We agree with Albala and his colleagues that a

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