Improvement in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Following γ-Globulin Infusion

To the Editor.  —Albala and his colleagues reported the improvement of neurologic function in one patient with a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) following γ-globulin infusion.¹ The rationale for this treatment was the beneficial treatment response following γ-globulin infusion in patients with idiopathic thrombocytopenic purpura and myasthenia gravis.The rationale could also have been the reported beneficial response in patients with CIDP, since Vermeulen et al² described improvement after fresh-frozen plasma and γ-globulin infusion in patients with CIDP.In this report,² 13 of 17 patients with CIDP improved after infusion of fresh-frozen plasma. Nine patients had γ-globulin infusions, and eight patients improved. The first signs of improvement were seen within eight days of the onset of treatment. None of these patients had spontaneous remissions for two months before these infusions, and none had immunosuppressive treatment during the infusions.We agree with Albala and his colleagues that a