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September 1987

Use of Enzyme-Linked Immunosorbent Assay in the Diagnosis of Cysticercosis

Author Affiliations

Unit of Immunology
Unit of Neurology Universidad Industrial de Santander Apartado Aéreo 678 Bucaramanga, Colombia

Arch Neurol. 1987;44(9):898. doi:10.1001/archneur.1987.00520210006006

To the Editor.  —We have read with interest the article by Rosas et al1 on the use of enzyme-linked immunosorbent assay (ELISA) in the diagnosis of cysticercosis.Due to the growing number of cases of cysticercosis found in Colombia, we have studied the clinical, epidemiologic, and immunologic characteristics of this disease.2 An ELISA has been standardized to detect the presence of IgG antibodies against cysticercal antigens in the serum and cerebrospinal fluid of patients with cysticercosis, obtaining a good sensitivity (89% ) and specificity (93%) in serum compared with normal individuals.2,3It is surprising that Rosas et al had not been able to standardize ELISAs to determine IgG antibodies. Cysticercosis is a chronic disease with incubation periods up to 30 years.4,5 In this situation, IgG determination is superior for diagnosis, such that the measurement of IgG antibodies, which are of greater significance during the acute phase of

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