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September 1987

Pharmacologic Probe With Progabide of GABA Mechanisms in Essential Tremor

Author Affiliations

From the Department of Neurology, Loyola University School of Medicine, Maywood, Ill, and Hines (Ill) Veterans Administration Hospital.

Arch Neurol. 1987;44(9):905-906. doi:10.1001/archneur.1987.00520210007009

• Progabide, a γ-aminobutyric acid agonist, was given to ten patients with essential tremor in a double-blind, placebo-controlled crossover study. The effect of progabide did not differ from that of placebo. Alterations in γ-aminobutyric acid neurotransmission do not appear to be involved in the pathogenesis of essential tremor.

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