• Progabide, a γ-aminobutyric acid agonist, was given to ten patients with essential tremor in a double-blind, placebo-controlled crossover study. The effect of progabide did not differ from that of placebo. Alterations in γ-aminobutyric acid neurotransmission do not appear to be involved in the pathogenesis of essential tremor.
Koller WC, Rubino F, Gupta S. Pharmacologic Probe With Progabide of GABA Mechanisms in Essential Tremor. Arch Neurol. 1987;44(9):905–906. doi:10.1001/archneur.1987.00520210007009
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