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January 1988

Cerebral Mucormycosis in Two Cases of Acquired Immunodeficiency Syndrome

Author Affiliations

From the Departments of Internal Medicine (Drs Cuadrado and Palau), Neurology (Drs Guerrero and Urra), and Pathology (Drs Asenjo and Martin), Hospital Clinico de San Carlos, Madrid.

Arch Neurol. 1988;45(1):109-111. doi:10.1001/archneur.1988.00520250119032

• We describe two patients with isolated cerebral mucormycosis and acquired immunodeficiency syndrome (AIDS). Their clinical course was rapid and fatal; early diagnosis and treatment with amphotericin B did not prevent a fatal outcome in both cases. Isolated cerebral mucormycosis has not (to our knowledge) been reported previously in patients with AIDS. Mucormycosis should be included in the differential diagnosis of central nervous system infections in intravenous drug abusers with AIDS. A brain biopsy is needed for the diagnosis of mucormycosis.

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