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February 1988

'Leuko-Araiosis' and Dementia

Author Affiliations

27800 Medical Center Rd Suite 210 Mission Viejo, CA 92691-6486

Arch Neurol. 1988;45(2):139-140. doi:10.1001/archneur.1988.00520260025010

To the Editor.  —We read with great interest the series of articles on "leuko-araiosis" and dementia recently published in the Archives.1-6 Our own investigations on incidental lesions noted on magnetic resonance imaging (MRI) of the brain were published recently.7,8 We wish to reconcile our own findings with those of Hachinski et al, and comment on the choice of the term "leuko-araiosis."Using MRI as the primary diagnostic modality, Awad et al7 studied the incidence, severity, and clinical correlates of incidental subcortical parenchymal foci of increased signal intensity in 240 consecutive patients undergoing MRI at a single institution. Lesions also visualized on computed tomography (CT) and cases with known or suspected demyelinating disease or recent brain trauma were excluded. Age, hypertension, and previous brain ischemia significantly and independently correlated with incidental MRI lesions. In an accompanying article, the postmortem pathologic correlates of such lesions were studied.8 There

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